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Since then scientists have discovered omalizumab is effective against even the most obscure forms of urticaria — from reactions to sunlight to changes in temperature, to friction. After just a week on omalizumab, he was a completely different person. By that estimate, there are only 32 people with the condition on the entire planet. Right from the beginning, aquagenic urticaria was as baffling to scientists as it is to the rest of us. The result is a patch of raised, itchy areas of skin known as welts. Later that day, scorching drops of the stuff start falling from the sky. Otherwise known as aquagenic urticaria, the condition is like being stung by a bush of particularly pernicious nettles, combined with the malaise of hay fever, every single day. People with an allergy can't even tolerate rain or snow on their skin Credit: Alamy.

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